Ag-Incorporated Polydopamine/Tannic Acid Coating on Titanium With Enhanced Cytocompatible and Antibacterial...

Area of Science:

• Biomaterials Science
• Surface Chemistry
• Nanotechnology

Background:

• Titanium (Ti) and its alloys are widely used for bone implants due to their biocompatibility.
• Bacterial infections remain a significant cause of implant failure, necessitating antibacterial strategies.
• Surface modification of Ti implants is crucial for enhancing their clinical performance and longevity.

Purpose of the Study:

• To develop a novel antibacterial coating for titanium (Ti) substrates.
• To investigate the efficacy of a polydopamine/tannic acid coating incorporating silver (Ag) ions.
• To evaluate the antibacterial activity and cytocompatibility of the modified Ti surface.

Main Methods:

• Cross-linking of dopamine and tannic acid on Ti via Michael addition and Schiff base reactions.
• Grafting of silver (Ag) ions onto the coating using redox reactions of phenolic hydroxyl groups.
• Characterization using SEM, EDS, water contact angle, FTIR, and XRD; assessment of antibacterial activity against *E. coli* and cytotoxicity with mouse fibroblast cells.

Main Results:

• Successful formation of an Ag-incorporated polydopamine/tannic acid coating on the Ti substrate.
• Demonstrated improvement in surface hydrophilicity.
• Effective antibacterial activity against Gram-negative *E. coli* and good cytocompatibility with mouse fibroblast cells.

Conclusions:

• The developed Ag-incorporated polydopamine/tannic acid coating exhibits significant antibacterial properties.
• The coating demonstrates good cytocompatibility, making it suitable for biomedical applications.
• This surface modification strategy holds potential for enhancing the performance and safety of titanium bone implants.