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Bone Formation in Pleomorphic Adenoma: A Case Report
Eb Robson Gubod1, Anand Ramanathan1,2, Sherrie Chong Mei Yee3
1Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, MYS.
Cureus
|April 8, 2022
Summary
Pleomorphic adenoma, a common benign salivary gland tumor, can rarely present with bone formation. This case highlights an unusual instance in a minor salivary gland, prompting further research into its clinical significance.
Area of Science:
- Oral and Maxillofacial Pathology
- Surgical Oncology
- Histopathology
Background:
- Pleomorphic adenoma is the most common benign salivary gland neoplasm.
- It exhibits diverse cytomorphological and architectural features.
- This tumor typically affects both pediatric and adult populations.
Observation:
- A 32-year-old woman presented with a slow-growing, painless, firm, and mobile nodule in the right mandibular angle.
- The nodule measured 1 cm x 1 cm and was palpable bimanually and intraorally in the retromolar area.
- Excisional biopsy revealed pleomorphic adenoma with prominent chondroid stroma and significant bone formation.
Findings:
- The histopathological examination confirmed pleomorphic adenoma with extensive stromal bone formation.
- This represents an exceptionally rare phenomenon, particularly in minor salivary gland tumors.
- The predominant stromal component was chondroid, with a notable area of ossification.
Implications:
- The pathogenesis and clinical significance of bone formation in pleomorphic adenoma remain poorly understood.
- Differential diagnosis should consider other bone-forming lesions in the maxillofacial region.
- Further follow-up studies are recommended to ascertain the clinical relevance and treatment outcomes for this rare variant.
