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Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
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Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

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Inhaling salbutamol may decrease time to exhaustion in some contexts of heavy endurance performances.

T Helge1, M Godhe1, B Berglund2

  • 1Åstrand Laboratory, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.

European Journal of Sport Science
|April 8, 2022
PubMed
Summary
This summary is machine-generated.

Inhaling salbutamol did not improve skiing performance but decreased time to exhaustion in elite cyclists. This study found no performance benefits for athletes using this beta-agonist.

Keywords:
Performancedopingendurancephysiologyrespiratory

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Area of Science:

  • Sports Science
  • Exercise Physiology
  • Pharmacology

Background:

  • Beta-agonists like salbutamol are sometimes used by athletes.
  • Elite athletes often seek performance-enhancing strategies.
  • The effects of salbutamol on athletic performance require investigation.

Purpose of the Study:

  • To investigate the impact of inhaled salbutamol versus placebo on elite athletes' performance.
  • To assess effects on skiing and cycling disciplines.

Main Methods:

  • Cross-over, double-blind, placebo-controlled design.
  • Elite skiers and cyclists performed specific exercise protocols.
  • Participants inhaled 800 µg salbutamol or placebo before tests.

Main Results:

  • No significant difference in ski sprint performance between salbutamol and placebo.
  • Time to exhaustion was 9.1% lower in cycling protocols after salbutamol.
  • Increased blood lactate, heart rate, and ventilation during submaximal cycling with salbutamol.

Conclusions:

  • Inhaling 800 µg salbutamol did not enhance skiing or high-intensity cycling performance.
  • Salbutamol potentially reduced time to exhaustion in elite cyclists.
  • Further research is needed to understand the physiological responses.