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Incorporating Insulin Growth Factor-1 into Regenerative and Personalized Medicine for Cardiovascular Disease: A
Quan Fu Gan1, Yi Ting Lim2, Chai Nien Foo3
1Pre-Clinical Department, Faculty of Medicine and Health Science, UTAR Sg Long Campus, Selangor, Malaysia.
Insights
Insulin Growth Factor-1 (IGF-1) shows promise for cardiovascular regeneration and treating cardiovascular disease (CVD). Further research is needed to address safety concerns like cancer growth before clinical application.
Area of Science:
- Regenerative Medicine
- Cardiovascular Science
- Biotechnology
Background:
- Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
- Current CVD treatments like PTCA and CABG have risks and complications impacting recovery.
- Insulin Growth Factor-1 (IGF-1) promotes cellular processes vital for cardiovascular regeneration.
Approach:
- This review synthesizes current research on integrating IGF-1 into regenerative medicine strategies.
- It identifies research gaps and challenges in translating IGF-1 therapies from laboratory to clinical settings.
- Literature search focused on IGF-1, mesenchymal stem cells, and tissue healing from 2009-2020.
Key Points:
- IGF-1 supports angiogenesis and cellular regeneration crucial for cardiovascular repair.
- Mesenchymal stem cells combined with IGF-1 show potential in tissue healing applications.
- Extensive screening of scientific literature identified relevant studies for review.
Conclusions:
- IGF-1 holds promise for personalized medicine approaches to CVD treatment.
- Potential risks, including IGF-1's role in cancer growth, require thorough investigation.
- Addressing safety and targeted delivery is essential for clinical translation of IGF-1 therapies.
Background:
Cardiovascular disease (CVD) is one of the world's leading causes of increased morbidity and mortality. Current interventions for CVD, including percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG), carry certain risks and complications, which may also affect the patient's quality of life. It is important to minimize those risks and complications while speeding up the recovery. Insulin Growth Factor-1 (IGF-1) is a growth factor responsible for cellular migration, proliferation, differentiation, and angiogenesis, which supports cardiovascular regeneration.
Methods:
In light of the current trend of regenerative medicine, the present review aims to pool data relating to the incorporation of IGF-1 in regenerative medicine and provide input on the current research gaps and concerns arising on translating this approach from benchwork into clinical settings.
Results:
Using the keywords IGF-1 'OR' Insulin Growth Factor 1 'AND' Mesenchymal Stem Cells 'AND' Tissue Healing from 2009 to 2020, we identified 160 and 52 from Medline and PubMed, screening out 202 articles due to non-fulfilment of the inclusion criteria.
Conclusion:
Incorporating IGF-1 into regenerative and personalized medicine may be promising for treating CVD; however, the concerns include the role of IGF-1 in inducing cancer growth and its ability to migrate to the specific site of injury, especially for those who present with multiple pathologies should be addressed prior to its translation from bench work into clinical settings.
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