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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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Cancer combination therapies by angiogenesis inhibitors; a comprehensive review

Mohammad Javed Ansari1, Dmitry Bokov2,3, Alexander Markov4,5

  • 1Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia.

Cell Communication and Signaling : CCS
|April 8, 2022
PubMed

Insights

Angiogenesis blockade therapy targets tumor vasculature but faces resistance. Combining it with other treatments like immunotherapy may improve cancer treatment outcomes.

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • Tumor vasculature is abnormal, aiding immune evasion and fueled by pro-angiogenic factors.
  • Angiogenesis blockade therapy, often targeting vascular-endothelium growth factor (VEGF), aims to starve tumors.
  • Resistance to anti-angiogenic agents and increased metastasis are significant challenges.

Purpose of the Study:

  • To review clinical developments in angiogenesis blockade therapy.
  • To explore combinations of angiogenesis blockade with conventional cancer treatments.

Main Methods:

  • Review of clinical studies and therapeutic strategies.
  • Focus on combination therapies including immunotherapy, chemoradiotherapy, targeted therapy, and cancer vaccines.

Main Results:

  • Angiogenesis blockade is a key strategy against cancer.
  • Combination therapies show promise in overcoming resistance and improving efficacy.
  • VEGF-targeted therapies are central but face challenges.

Conclusions:

  • Angiogenesis blockade therapy is crucial in cancer treatment.
  • Combining anti-angiogenic strategies with immunotherapy, chemoradiotherapy, targeted therapy, and cancer vaccines is a promising clinical development.
  • Further research into combination therapies is essential to enhance anti-cancer effects and overcome resistance.
Keywords:
AngiogenesisAnti-angiogenic agentsCombination therapyResistanceTumor

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