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Hurthle cell thyroid tumors. An immunohistochemical study.

T L Johnson, R V Lloyd, R E Burney

    Cancer
    |January 1, 1987
    PubMed
    Summary

    Hurthle cell tumors of the thyroid, both benign and malignant, produce thyroglobulin and express CEA and p21 ras oncogene product. Distinguishing between benign and malignant types still relies on traditional histologic features.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Hurthle cell neoplasms are a subset of thyroid tumors.
    • Immunohistochemical markers can aid in tumor characterization.

    Purpose of the Study:

    • To investigate the expression of thyroglobulin, CEA, and p21 ras oncogene product in Hurthle cell neoplasms.
    • To determine if these markers can differentiate between benign and malignant Hurthle cell tumors.

    Main Methods:

    • Immunohistochemical analysis of 23 Hurthle cell neoplasms.
    • Assessment of thyroglobulin, carcinoembryonic antigen (CEA), and p21 ras oncogene product expression.
    • Clinicopathologic correlation.

    Main Results:

    • Both benign and malignant Hurthle cell tumors stained positively for thyroglobulin.
    • Most tumors expressed CEA and p21 ras oncogene product.
    • Malignant tumors were larger, occurred in older patients, and had a similar sex distribution compared to benign tumors.

    Conclusions:

    • Thyroglobulin, CEA, and p21 ras oncogene product are expressed in both benign and malignant Hurthle cell thyroid tumors.
    • Current immunohistochemical markers are not sufficient to distinguish between benign and malignant Hurthle cell neoplasms.
    • Traditional histologic features remain crucial for diagnosis.

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