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Essential thrombocythemia and aortic dissection,causal or incidental association?
Nabil Laktib1, El Mehdi Mahtat2, Zakaria Lahlafi3
1Department of Cardiology Intensive Care Unit, Cardiology Center of Mohammed V Military Training Hospital, Rabat, Morocco.
Journal De Medecine Vasculaire
|April 8, 2022
Summary
A rare association between aortic dissection and essential thrombocythemia (a blood disorder) was observed in a JAK2V617F-positive male. This case highlights potential causal links and suggests hydroxyurea for thrombosis prevention in myeloproliferative neoplasms.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Oncology
Background:
- Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts.
- Vascular complications, including dissection, are known risks in ET, though rarely reported.
- The JAK2V617F mutation is a common driver mutation in ET.
Observation:
- A 60-year-old male presented with aortic dissection.
- The patient had a confirmed JAK2V617F mutation and essential thrombocythemia.
- No prior history of hypertension or connective tissue disorders was noted.
Findings:
- This case represents the second reported instance of aortic dissection associated with essential thrombocythemia.
- The JAK2V617F mutation in ET may contribute to vascular dissection risk.
- The findings prompt discussion on a potential causal relationship between ET and aortic dissection.
Implications:
- Further research is warranted to elucidate the causal link between essential thrombocythemia and aortic dissection.
- Hydroxyurea may be a valuable prophylactic treatment for preventing thrombosis in patients with myeloproliferative neoplasms.
- This case underscores the importance of considering thrombotic risks in ET patients, even without traditional risk factors.
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