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Updated: Sep 27, 2025

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation

Published on: July 17, 2018

Bioactive Scalarane-Type Sesterterpenoids from Marine Sources.

Hao-Bing Yu¹, Hai-Yan Chen², Song Duan¹

¹Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.

Chemistry & Biodiversity

|April 8, 2022

Summary

Scalarane-type sesterterpenoids from marine organisms show diverse biological activities. This review summarizes 221 compounds isolated between 2010-2021, focusing on their anticancer potential.

Keywords:

bioactivity marine natural products scalarane-type sesterterpenoids

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Area of Science:

Marine Natural Products Chemistry
Medicinal Chemistry
Pharmacology

Background:

Scalarane-type sesterterpenoids are a class of marine natural products known for complex structures.
These compounds are primarily isolated from marine sponges and nudibranchs.
They exhibit a wide range of biological and pharmacological properties.

Purpose of the Study:

To comprehensively review marine-derived scalarane-type sesterterpenoids.
To detail their chemical structures and biological properties, with a focus on anticancer activity.
To critically summarize 221 compounds reported between January 2010 and December 2021.

Main Methods:

Literature review and data compilation.
Chemical structure elucidation and characterization.
Analysis of reported biological activities, particularly anticancer effects.

Main Results:

Identification of marine sponges and nudibranchs as key sources.
Detailed listing of 221 scalarane-type sesterterpenoids.
Emphasis on compounds with demonstrated anticancer potential.

Conclusions:

Marine-derived scalarane sesterterpenoids represent a rich source of potential anticancer agents.
Continued research into these compounds may yield novel therapeutic leads.
This review provides a valuable resource for researchers in natural products and medicinal chemistry.