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Advances in aptamer-based nuclear imaging.

Wenyu Song^1,2, Yangmeihui Song^1,2, Qian Li³

¹Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, China.

European Journal of Nuclear Medicine and Molecular Imaging

|April 8, 2022

Summary

This summary is machine-generated.

Aptamers, short DNA or RNA molecules, show promise for nuclear imaging of tumors. This review highlights their advances and potential as versatile radiotracers for cancer diagnostics.

Keywords:

Aptamer Cancer Nuclear imaging Nuclear medicine Radiopharmaceutical

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Area of Science:

Biomedical applications
Molecular imaging
Oligonucleotide-based diagnostics

Background:

Aptamers are short oligonucleotides with specific target-binding capabilities.
They are increasingly utilized in biosensing, medical imaging, and therapeutic applications.
Their tunable affinity makes them suitable for molecular imaging, particularly for detecting tumors.

Purpose of the Study:

To review recent advancements in aptamer-based nuclear imaging.
To compare aptamer tracers with other biogenic probes.
To discuss the properties and future potential of aptamer radiotracers.

Main Methods:

Review of current literature on aptamer-based nuclear imaging.
Comparative analysis of aptamers against peptides, nanobodies, antibodies, and antibody fragments.
Discussion of fundamental properties and optimization strategies for aptamer radiotracers.

Main Results:

Aptamers demonstrate significant potential as tracers for nuclear imaging of tumors.
They offer advantages in terms of specificity and adjustable affinity compared to other probes.
Key properties influencing imaging performance have been identified.

Conclusions:

Aptamers represent a versatile tool for cancer nuclear imaging.
Further development is needed to overcome translational challenges.
Aptamers are poised to become important in preclinical and clinical cancer diagnostics.