Related Experiment Video
Updated: Sep 27, 2025
07:14
Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
Published on: May 23, 2025
686
An Ascendant Challenge: Central Nervous System Metastases in ALK+ Lung Cancers
Yonina R Murciano-Goroff1, Guilherme Harada1, Alexander Drilon1,2
1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
Central nervous system (CNS) metastases constitute a challenge for the design of anaplastic lymphoma kinase (ALK) fusion-positive lung cancer trials. The ASCEND-7 study of ceritinib demonstrates the feasibility of broadening CNS eligibility criteria to include symptomatic brain and leptomeningeal disease and highlights design features that contemporary trials will need to incorporate. See related article by Chow et al., p. 2506.
