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Related Experiment Video

Updated: Sep 27, 2025

Extraction of Structural Extracellular Polymeric Substances from Aerobic Granular Sludge

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Published on: September 26, 2016

Foam fractionation methods in aerobic fermentation processes.

Amira Oraby^1,2, Isabell Weickardt¹, Susanne Zibek^1,2

¹Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany.

Biotechnology and Bioengineering

|April 8, 2022

Summary

Foam fractionation during aerobic fermentation offers a non-disruptive method for product recovery and concentration. Engineering specific foam fractionation designs is key for industrial application of this downstream processing technique.

Keywords:

ISPR fermentation foam fractionation foaming integrated

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Area of Science:

Biotechnology
Biochemical Engineering
Downstream Processing

Background:

Aerobic fermentation of surface-active compounds often produces foam.
Foam formation can be leveraged for downstream processing, including product concentration and in situ recovery.
Existing foam prevention methods can interfere with fermentation parameters or broth composition.

Purpose of the Study:

To review and classify foam fractionation designs and methods for aerobic fermentation.
To analyze substance-specific characteristics relevant to foam fractionation.
To discuss challenges and future perspectives for industrial application.

Main Methods:

Systematic literature review.
Analysis of design aspects and process demands for foam fractionation in fermentation.
Classification of foam fractionation techniques.
Evaluation of substance-specific characteristics.

Main Results:

Foam fractionation is a viable first downstream processing step for product concentration and in situ recovery.
Foam fractionation does not interfere with fermentation parameters or alter broth composition.
Specific foam fractionation designs require individual engineering due to complex influencing parameters, hindering widespread industrial adoption.

Conclusions:

Foam fractionation presents a promising, non-invasive downstream processing strategy for aerobic fermentations.
Standardized engineering approaches and further research are needed to overcome challenges and promote industrial application.
Understanding substance-specific properties is crucial for optimizing foam fractionation processes.