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Updated: Sep 27, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
Published on: June 14, 2016
[Extracellular matrix remodeling as a risk factor for the progression of cerebrovascular pathology]
E F Barinov1, E A Statinova1, T I Faber1
1Gorky Donetsk National Medical University, Donetsk, Ukraine.
Abstract:
In recent years, attention of experts has been attracted to remodeling of the brains' extracellular matrix in connection with analysis of alterations' causes of the blood-brain barrier (BBB), development of neuroinflammation and neovasculogenesis, as well as the possibility of regeneration of nervous tissue in cerebrovascular pathology. The review discusses the molecular mechanisms of increasing BBB permeability in stroke associated with the interaction of structural elements of the capillary wall (endothelium and pericytes), glial cells and perivascular leukocytes. The role of brain extracellular matrix remodeling in the pathogenesis of neuroinflammation and participation of pericytes in this process are discussed. Management of remodeling process of structural elements in extracellular matrix may be a promising new technology in the treatment of patients with cerebrovascular pathology.
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