Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.4K

Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine

Petro V Kuzyk1, Rachel Padilla2, Natasha R Rybak3

  • 1Department of Pathological Anatomy, Bogomolets National Medical University, Kyiv, Ukraine.

Journal of the Pediatric Infectious Diseases Society
|April 8, 2022
PubMed

Insights

Pediatric tuberculosis (TB) caused significant mortality in Ukrainian children, with 14 cases unrecognized or untreated at autopsy. Improved diagnostics and early identification strategies for childhood TB are crucial.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pathology

Background:

  • Tuberculosis (TB) remains a global health concern, particularly in vulnerable pediatric populations.
  • Accurate diagnosis of TB in children can be challenging, leading to delayed or missed treatment.
  • Autopsy data provides valuable insights into causes of death, including infectious diseases.

Purpose of the Study:

  • To determine the prevalence of unrecognized or untreated pediatric tuberculosis (TB) at autopsy in Lviv, Ukraine.
  • To highlight the impact of undiagnosed TB on child mortality.
  • To underscore the need for enhanced TB detection methods in children.

Main Methods:

  • Retrospective review of autopsy records from general hospitals in Lviv, Ukraine.
  • Analysis of data from 2345 autopsied children.
  • Identification of cases with confirmed tuberculosis (TB) that were unrecognized or untreated prior to death.

Main Results:

  • Fourteen cases (0.6%) of pediatric tuberculosis (TB) were identified during autopsy.
  • These cases represented children with unrecognized or untreated TB.
  • The findings indicate a significant burden of undiagnosed TB in the pediatric population studied.

Conclusions:

  • Undiagnosed and untreated tuberculosis (TB) contributes to pediatric mortality.
  • There is an urgent need for more sensitive diagnostic tools for TB in children.
  • Improved strategies are required to effectively identify children needing TB evaluation and treatment.

Keywords:
diagnosticsmeningitispostmortemtuberculosis

More Related Videos

A Tuberculosis Molecular Bacterial Load Assay TB-MBLA10:41

A Tuberculosis Molecular Bacterial Load Assay TB-MBLA

Published on: April 30, 2020

14.3K
Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS09:58

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS

Published on: April 18, 2018

9.2K

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
216
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
343
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
255
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
477
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
481