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Updated: Sep 27, 2025

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
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Lassa Virus Infection: a Summary for Clinicians.

Vanessa Raabe1, Aneesh K Mehta2, Jared D Evans3

  • 1New York University Grossman School of Medicine, New York, NY.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|April 8, 2022
PubMed
Summary

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Journal of virology·2024

Lassa virus (LASV) infection and Lassa fever disease (LF) lack approved treatments, but investigational therapies and vaccines show promise. This review offers clinicians a rapid reference for managing suspected LASV cases with current and emerging medical countermeasures.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Lassa virus (LASV) causes Lassa fever (LF), a severe hemorrhagic illness endemic to West Africa.
  • Clinical manifestations of LF range from mild to life-threatening, posing significant public health challenges.

Purpose of the Study:

  • To provide clinicians with a condensed, accessible summary of current literature on LASV infection and LF.
  • To highlight potential therapies and vaccines for LF based on clinical and research evidence.

Main Methods:

  • An integrative literature review was conducted focusing on clinical and pathological features, vaccines, and treatments for LASV infection.
  • Emphasis was placed on recent studies and in vivo evidence from humans and non-human primates (NHPs).
Keywords:
Lassa feverLassa virusantiviral countermeasureantiviral therapyvaccineviral hemorrhagic fever

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Main Results:

  • Two antiviral medications show potential for LASV treatment, and one for post-exposure prophylaxis.
  • Multiple vaccine platforms are in pre-clinical development, but human clinical trial data are pending.

Conclusions:

  • No approved drugs or vaccines currently exist for LF, but investigational options are emerging.
  • This review serves as a rapid reference for clinicians managing suspected LASV infections, including treatment options and control measures.