Related Experiment Video
Updated: Sep 27, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
The anterior and centromedian thalamus: Anatomy, function, and dysfunction in epilepsy
Nebras M Warsi1, Han Yan2, Hrishikesh Suresh1
1Division of Neurosurgery, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada; Department of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Abstract:
The thalamus is a densely connected collection of nuclei that play a critical role in gating information flow across the neocortex. Through diffuse reciprocal cortico-thalamo-cortical connectivity, the anterior and centromedian nuclei exert remarkable control over cortically expressed activity. Consequently, mounting evidence implicates these thalamic centres in both the genesis and propagation of aberrant epileptiform activity across the brain. The present work reviews existing literature with regards to the anatomy, function, and dysfunction of the anterior and centromedian thalamic nuclei as they relate to epileptogenesis and ictal dynamics in humans. A confluence of electrophysiological, anatomical, and neuromodulatory evidence links these thalamic hubs to a variety of epilepsy syndromes. These data are discussed as they relate to targeted thalamic neuromodulation.
More Related Videos
12:09Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
09:00Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
Published on: April 15, 2015
Related Concept Videos
Diencephalon: Anatomical Regions
Diencephalon: Thalamus and Information Relay
Antiepileptic Drugs: Glutamate Antagonists
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Anatomy of the Brain: Major Regions
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
Functional Brain Systems: Limbic System