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The effect of dexmedetomidine on neuroprotection in pediatric cardiac surgery patients: study protocol for a

Sang-Hwan Ji1, Pyoyoon Kang1, In-Sun Song1

  • 1Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Trials
|April 9, 2022
PubMed

Insights

Dexmedetomidine may protect infants from neurodevelopmental delays after heart surgery. This study investigates its neuroprotective effects and impact on other organs in infants undergoing cardiopulmonary bypass.

Area of Science:

  • Pediatric Cardiac Surgery
  • Neuroprotection
  • Pharmacology

Background:

  • Infants undergoing cardiopulmonary bypass for cardiac surgery face risks of neurodevelopmental delays.
  • Dexmedetomidine demonstrates potential organ-protective effects in preclinical and adult studies.
  • This research explores dexmedetomidine's neuroprotective capacity in infants during cardiac surgery.

Purpose of the Study:

  • To evaluate the neuroprotective effect of dexmedetomidine in infants undergoing cardiac surgery with cardiopulmonary bypass.
  • To assess the impact of dexmedetomidine on early neurodevelopmental outcomes.
  • To examine dexmedetomidine's effects on other organ systems and perioperative adverse events.

Main Methods:

  • A prospective, double-blind, randomized controlled trial involving 160 infants.
  • Infants received either dexmedetomidine infusion or a placebo (normal saline).
  • Primary outcome: neurodevelopmental scores (Bayley Scales of Infant Development-III) at 1 year; secondary outcomes: biomarkers and adverse events.

Main Results:

  • The study is designed to determine if dexmedetomidine reduces the incidence of neurodevelopmental delays.
  • It will also compare changes in biomarkers like glial fibrillary acidic protein and troponin I.
  • Perioperative major adverse events will be analyzed between groups.

Conclusions:

  • This trial will ascertain if dexmedetomidine use improves early neurodevelopmental outcomes in infants post-cardiac surgery.
  • The study will provide insights into dexmedetomidine's broader organ-protective effects.
  • Findings will inform clinical practice regarding perioperative medication in pediatric cardiac surgery.
Abstract

Keywords:
Cardiopulmonary bypassCongenital heart diseaseDexmedetomidineInfantNeuroprotectionRandomized controlled trial

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