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Published on: July 3, 2014
Mediastinal irradiation and valvular heart disease
Shivaraj Patil1, Srinath-Reddi Pingle2, Khalid Shalaby1
1Department of Internal Medicine, University of Connecticut Heath Center, Farmington, CT, USA.
Abstract:
Anticancer therapy has the potential to cause unwanted cardiovascular side effects. Utilization of radiation therapy to treat tumors near the heart can result in radiation-induced valvular heart disease among other cardiovascular pathologies. The aim of this review is to describe the epidemiology, pathophysiology, risk prediction, non-invasive imaging modalities and management of radiation-induced valvular heart disease with a focus on pre-operative risk assessment and contemporary treatment options.
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