Migration of an active colloidal cell in inhomogeneous environments

Living cells on a substrate with mechanical inhomogeneities often migrate along or against the mechanical gradient, i.e., mechanotaxis, which inspires us to ask how biomimetic cells without biochemical signaling processes respond to environmental inhomogeneity. Here, we perform computer simulations to study the migration of a 2D active colloidal cell (ACC), which consists of active particles enclosed by a passive vesicle, in a heterogeneous environment composed of two adjoining uniform regions with different attributes (influencing the persistent length of the active particle). We find that the ACC can migrate unidirectionally across the interface separating the heterogeneous region and behave tactically. Interestingly, the tactic motion of the ACC is qualitatively different from that of the constituent active particles themselves. In addition, the ACC may also experience a directed drift along the interface of the heterogeneous environment. The tactic behavior of the ACC can be explained by analyzing the pressure distribution on the cell membrane exerted by the enclosed active particles. The findings provide insights into understanding the taxis of biological cells and designing biomimetic cells with environment-sensitive capabilities.