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Current advances in cell therapeutics: a biomacromolecules application perspective.
Samson A Adeyemi1, Yahya E Choonara1
1Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road 2193, Parktown, South Africa.
Smart biomacromolecules are revolutionizing cell therapeutics for chronic diseases. These natural hydrogel-forming materials enhance cell encapsulation and delivery for targeted treatments.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Conventional therapies face limitations for chronic diseases.
- Cell therapeutics offer a promising alternative for targeted treatment.
- Biomacromolecules mimicking the extracellular matrix are ideal for cell delivery.
Purpose of the Study:
- To review advancements in biomacromolecules for smart cell delivery systems.
- To discuss the role of biomacromolecules in enhancing cell encapsulation and delivery.
- To outline principles of cell therapeutics in major diseases.
Main Methods:
- Review of current literature on biomacromolecules and cell therapeutics.
- Analysis of biomaterial design for cell carrier assembly.
- Discussion of therapeutic applications in various disease models.
Main Results:
- Biomacromolecules, particularly natural hydrogels, show high compatibility for cell encapsulation.
- Smart carriers enhance targeted delivery of therapeutic cells.
- Progress in biomaterial design is crucial for effective cell therapeutics.
Conclusions:
- Cell therapeutics hold potential to revolutionize treatment for secretory cell dysfunctions.
- Functional biomacromolecule design is key for safe and potent cell delivery.
- Continued research in biomaterials will advance cell-based therapies.
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