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Related Experiment Video

Updated: Sep 27, 2025

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
06:18

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Lodenafil.

Yahya M Alshehri1, Abdulrahman A Al-Majed2, Mohamed W Attwa2

  • 1College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|April 9, 2022
PubMed
Summary
This summary is machine-generated.

Lodenafil carbonate is a prodrug that enhances oral bioavailability for treating erectile dysfunction. This review covers its properties, preparation, and therapeutic applications.

Keywords:
Analytical methodsClinical applicationsHydroxyhomosildenafilLodenafilNMRPDE5 inhibitors drugsPhysical descriptionStabilitySynthesis methods

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Area of Science:

  • Pharmacology
  • Medicinal Chemistry

Background:

  • Lodenafil is a phosphodiesterase type 5 (PDE5) inhibitor, similar to sildenafil, tadalafil, and vardenafil.
  • It belongs to a new generation of PDE5 inhibitors, including udenafil and avanafil.

Purpose of the Study:

  • To provide a comprehensive literature review of lodenafil.
  • To detail its description, preparation, properties, and therapeutic uses.

Main Methods:

  • Critical review of existing literature on lodenafil.
  • Analysis of lodenafil carbonate formulation and its properties.

Main Results:

  • Lodenafil carbonate, a prodrug, offers higher oral bioavailability than the parent drug.
  • The review covers lodenafil's chemical, physical, pharmacological, and toxicological aspects.

Conclusions:

  • Lodenafil carbonate is a promising formulation for PDE5 inhibition.
  • This review consolidates essential information for researchers and clinicians.