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Updated: Sep 27, 2025

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
Renal cell carcinoma uvula metastasis leading to airway compromise: an unusual site
Jennifer Wallace1, Edgardo Abelardo2,3, Kannan Ramachandran2
1Otolaryngology, Glangwili General Hospital, Carmarthen, UK Jennifer.wallace1@nhs.net.
Abstract:
We present a case report of a gentleman presenting with a globular lesion arising from his uvula. Although elective admission was planned, he presented with airway compromise, and emergency excision was required. The patient had a background of metastatic clear cell renal carcinoma; histology confirmed the uvula lesion as a further secondary deposit. Renal cell carcinoma has a recognised metastatic propensity, but spread to the uvula is rare, with only two previously described cases in the literature. This case is notable for the unusual location of the metastasis, as well as the rapid progression of symptoms, which threatened the airway and necessitated urgent surgical intervention.
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