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ROCK2-induced metabolic rewiring in diabetic podocytopathy

Keiichiro Matoba1, Yusuke Takeda2, Yosuke Nagai2

  • 1Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105-8461, Japan. matoba@jikei.ac.jp.

Communications Biology
|April 9, 2022
PubMed
Summary

Podocyte Rho-associated coiled-coil containing protein kinase 2 (ROCK2) is activated in diabetes, driving kidney injury. Inhibiting ROCK2 in podocytes protects against diabetic kidney disease, suggesting ROCK2 as a therapeutic target.

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