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A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk

Zeinab Yazdanpanah1,2, Hassan Mozaffari-Khosravi1,2,3, Masoud Mirzaei4

  • 1Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, PO Code 8915173160, Iran.

Scientific Reports
|April 9, 2022
PubMed

Insights

The CD36 rs1761667 polymorphism is linked to triglyceride levels and potentially HDL-C and fasting blood glucose. Further research is needed to confirm these associations across diverse populations.

Area of Science:

  • Cardiovascular Disease Genetics
  • Metabolic Syndrome Research
  • Molecular Biology

Background:

  • Cluster of Differentiation 36 (CD36) plays a key role in cardiovascular disease development.
  • Genetic variations, such as polymorphisms, can influence an individual's susceptibility to cardiometabolic risk factors.
  • Understanding the genetic underpinnings of CD36 is crucial for identifying individuals at higher risk.

Purpose of the Study:

  • To investigate the association between the CD36 rs1761667 polymorphism and various cardiometabolic risk factors.
  • To evaluate the relationship with body mass index (BMI), waist circumference (WC), lipid profiles (total cholesterol, triglyceride, HDL-C, LDL-C), blood pressure, and fasting blood glucose (FBG).
  • To explore potential heterogeneity and subgroup differences in the observed associations.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, EMBASE, Scopus, Web of Science, Google Scholar) up to December 2021.
  • Meta-analysis and meta-regression techniques were employed to synthesize data from eligible studies.
  • Eighteen studies involving 6317 participants were included in the final analysis.

Main Results:

  • A significant association was identified between the CD36 rs1761667 polymorphism and triglyceride levels across allelic, recessive, and homozygous models.
  • The recessive genetic model revealed a relationship between this polymorphism and HDL-C and fasting blood glucose levels.
  • Subgroup analysis indicated that the A allele was associated with impaired lipid profiles (TC, LDL-C, HDL-C) specifically in Asian populations.

Conclusions:

  • The CD36 rs1761667 polymorphism is associated with altered triglyceride levels and potentially impacts HDL-C and FBG.
  • Genetic variations in CD36 may contribute to cardiometabolic risk, with population-specific effects observed.
  • Future large-scale cohort studies in diverse ethnicities are recommended to validate these findings and elucidate the precise role of this SNP.

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