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Non-invasive ways of administering insulin
Ivana Rizk El Maalouf1, Kam Capoccia2, Ronny Priefer1
1Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, USA.
Diabetes & Metabolic Syndrome
|April 9, 2022
Summary
Exploring needle-free insulin delivery, this review covers novel non-invasive methods for diabetes management. These approaches aim to improve absorption and bioavailability, offering alternatives to traditional injections.
Area of Science:
- Pharmacology and Drug Delivery
- Endocrinology
- Biomedical Engineering
Background:
- Insulin therapy is essential for diabetes management but faces challenges with subcutaneous injections.
- Needle-free insulin delivery systems are being developed to enhance patient compliance and therapeutic outcomes.
- Research focuses on overcoming barriers to insulin absorption and bioavailability through alternative routes.
Purpose of the Study:
- To review novel non-invasive insulin administration approaches.
- To delineate the advantages and disadvantages of these alternative delivery systems.
- To assess their potential for improving diabetes management.
Main Methods:
- Systematic literature search of PubMed and supplementary manuscripts from 1958-2022.
- Evaluation of articles for real-world examples and data extraction.
- Introductive approach to identify various insulin administration concepts.
Main Results:
- Investigated routes include oral, buccal, intranasal, inhalation, transdermal, ocular, rectal, and vaginal.
- Some methods demonstrated clinical efficacy in improving blood glucose levels.
- Other novel delivery systems remain in the investigational phase.
Conclusions:
- Multiple strategies aim to overcome physical barriers in insulin delivery.
- Future non-invasive insulin systems may offer alternatives to subcutaneous injections.
- These advancements hold promise for millions of diabetes patients worldwide.
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