Anti-cancer peptide-based therapeutic strategies in solid tumors
Mohsen Karami Fath1, Kimiya Babakhaniyan2, Maryam Zokaei3,4
1Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Background:
Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively.
Result:
Introducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology.
Conclusion:
This study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed.
Insights
Therapeutic peptides offer a promising strategy for targeted cancer treatment, selectively delivering drugs to tumor cells. This review explores novel peptides and their applications in various cancer types.
Area of Science:
- Oncology
- Biotechnology
- Peptide Therapeutics
Background:
- Conventional cancer treatments like surgery, radiotherapy, and chemotherapy have limitations in curing all cancer types.
- Tumor-targeting peptides represent a promising approach for selective drug delivery to solid tumors.
- Therapeutic peptides are being investigated as novel agents for cancer treatment.
Discussion:
- Therapeutic peptides offer high selectivity, specificity, biocompatibility, and ease of modification for targeted drug delivery.
- Their small dimensions and ability to penetrate cells make them ideal for delivering active agents.
- Peptides are increasingly recognized for their potential in cancer research, nanotechnology, and targeted therapies.
Key Insights:
- This review details various therapeutic peptides and targeting ligands for cancer therapy.
- Three types of tumor-homing and cell-penetrating peptides (CPPs) are described.
- Applications of these peptides in breast, glioma, colorectal, and melanoma cancer research are discussed.
Outlook:
- Further research into therapeutic peptides can lead to novel cancer treatments.
- Peptide-based drug delivery systems hold significant promise for improving therapeutic outcomes.
- The development of targeted peptide therapies could revolutionize oncology.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
01:27Tumor Immunotherapy
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...