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Endogenous endophthalmitis caused by Streptococcus suis infection: a case report
1Department of Ophthalmology, Subei Peoples' Hospital Affiliated to Yangzhou University, Yangzhou, China.
Background:
Streptococcus suis (S. suis) is an emerging zoonotic human pathogen, which commonly causes meningitis and sepsis. Ocular infections associated with S. suis infection are very rare. Herein, we reported a rare case of a man who developed endophthalmitis complicated by meningitis following S. suis infection.
Case Presentation:
A 48-year-old male with a fever, loss of vision in the right eye, slight headache, and hearing loss in the right ear was admitted to our hospital. A comprehensive ophthalmological examination suggested endophthalmitis. The metagenomics next-generation sequencing (mNGS) results of pathogenic microorganisms from vitreous and cerebrospinal fluid samples revealed that the causative pathogen was S. suis, which was further confirmed by the bacterial culture of the vitreous sample. Subsequently, the patient received phacoemulsification and vitrectomy, combined with silicone oil tamponade, as well as local and systemic anti-infective therapy, after which his condition significantly improved.
Conclusions:
Despite the low incidence rate of endophthalmitis caused by S. suis, clinicians should be aware of relevant clinical manifestations, especially for patients with neurological symptoms and risk factors for S. suis infection. The next-generation sequencing is efficient for etiological diagnosis of pathogenic microorganisms.
Insights
This case report details a rare instance of Streptococcus suis (S. suis) causing endophthalmitis and meningitis in a man. Early diagnosis via metagenomics next-generation sequencing led to successful treatment and improved outcomes.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Streptococcus suis (S. suis) is an emerging zoonotic pathogen known for causing meningitis and sepsis.
- Ocular infections due to S. suis are exceptionally rare, making this case noteworthy.
Observation:
- A 48-year-old male presented with fever, vision loss in the right eye, headache, and hearing loss.
- Ophthalmological examination indicated endophthalmitis; metagenomics next-generation sequencing (mNGS) identified S. suis in vitreous and cerebrospinal fluid.
Findings:
- S. suis was confirmed as the causative agent through bacterial culture of the vitreous sample.
- The patient underwent surgical intervention (phacoemulsification, vitrectomy, silicone oil tamponade) and received anti-infective therapy.
Implications:
- Clinicians should consider S. suis in patients with neurological symptoms and risk factors, particularly those with ocular manifestations.
- Metagenomics next-generation sequencing (mNGS) proves effective for rapid etiological diagnosis of rare infectious agents.
- This case highlights the importance of recognizing S. suis as a potential cause of endophthalmitis, even with its low incidence.
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