Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

38
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardized End Point Definitions for Clinical Trials in Thoracic Aortic Repair: A Consensus Report From the ARCH-Academic Research Consortium.

Circulation·2026
Same author

Surgeons' Perceptions on the Utility of a Conceptual Novel Force Sensor at the Surgeon-Tool Interface: Formative Interview Study.

JMIR formative research·2026
Same author

Holographic diffusers for endoluminal-scale optical ultrasound imaging.

Journal of biomedical optics·2026
Same author

Multicentre Retrospective Cohort Study on Current Practices in Treatment of Patients Presenting with Non-A Non-B Aortic Dissection and Factors Predicting the Need for Intervention and Mortality.

Journal of clinical medicine·2026
Same author

Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Sustained real-time and video-rate interventional optical ultrasound imaging.

Journal of biomedical optics·2025

Related Experiment Video

Updated: Sep 27, 2025

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
09:32

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

15.5K

A patient-specific multi-modality abdominal aortic aneurysm imaging phantom.

Callum D Little1,2,3, Eleanor C Mackle1,2, Efthymios Maneas1,2

  • 1Wellcome Trust-EPSRC Centre for Interventional and Surgical Sciences, London, W1W 7TS, UK.

International Journal of Computer Assisted Radiology and Surgery
|April 10, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a low-cost, realistic model of an abdominal aortic aneurysm that can be seen using both CT scans and ultrasound. This tool helps doctors practice surgery and allows engineers to test new medical devices without using patients.

Keywords:
Abdominal aortic aneurysmImaging phantomsTissue-mimicking materialUltrasoundVascular3D printingvascular simulationendovascular repairmedical training tools

Frequently Asked Questions

More Related Videos

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
06:33

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

11.4K
Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning
08:41

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning

Published on: July 14, 2020

8.6K

Related Experiment Videos

Last Updated: Sep 27, 2025

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
09:32

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

15.5K
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
06:33

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

11.4K
Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning
08:41

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning

Published on: July 14, 2020

8.6K

Area of Science:

  • Vascular imaging research within abdominal aortic aneurysm diagnostics
  • Biomedical engineering for patient-specific phantom development

Background:

No prior work had resolved the challenge of creating versatile phantoms compatible with diverse imaging systems. Current vascular models often lack the necessary fidelity for both radiation and sound-based visualization techniques. This gap motivated the development of new tools to improve pre-clinical device testing. Prior research has shown that reducing ionizing radiation exposure remains a priority in modern clinical practice. That uncertainty drove the need for realistic, non-human testing platforms for vascular interventions. Surgical trainees require high-quality simulation tools to master complex endovascular procedures safely. Existing solutions frequently fail to replicate patient-specific anatomy with sufficient accuracy for advanced training. This study addresses these limitations by proposing a novel fabrication method for abdominal aortic aneurysm models.

Purpose Of The Study:

The aim of this study is to propose a temperature-stable, high-fidelity method for creating complex abdominal aortic aneurysm phantoms. Researchers sought to address the need for models compatible with both radiation-based and ultrasound-based imaging modalities. This work focuses on utilizing low-cost materials to improve accessibility for pre-clinical device testing. The team intended to provide a platform that facilitates comparisons in research settings. Additionally, the study explores the benefits of these phantoms for surgical trainees gaining experience with new techniques. The motivation stems from the increasing awareness of ionizing radiation dangers in clinical environments. By creating patient-specific structures, the authors hope to enhance the realism of simulation tools. This effort seeks to bridge the gap between patient anatomy and benchtop testing requirements.

Main Methods:

The Review Approach involved acquiring volumetric computed tomography data from a patient with an abdominal aortic aneurysm. Researchers performed segmentation on specific regions of interest to generate a 3D printable model. The team utilized water-soluble materials to print wall-less vascular structures representing the patient anatomy. These structures were subsequently embedded within tailored tissue-mimicking materials to replicate surrounding biological environments. A non-soluble 3D printed spine was integrated to serve as a fixed radiological landmark. The fabrication process prioritized the use of low-cost materials to ensure accessibility. Investigators evaluated the resulting phantom using multiple imaging systems to confirm compatibility. Finally, the utility of the model was tested during a simulated endovascular aneurysm repair procedure.

Main Results:

Key Findings From the Literature indicate that the hybrid fabrication method successfully produces realistic, patient-derived vascular phantoms. The models provided accurate visual representations during intravascular ultrasound, computed tomography, and transcutaneous ultrasound assessments. The inclusion of a non-soluble spine effectively provided a necessary radiological landmark for navigation. During simulated endovascular aneurysm repair, the phantom demonstrated utility for training with image fusion. The temperature-stable design maintained fidelity across the tested imaging modalities. These results confirm that complex vascular structures can be created using the described hybrid approach. The study provides evidence that these phantoms are compatible with both radiation-based and ultrasound-based systems. The findings support the use of these models for benchtop development and surgical training applications.

Conclusions:

The authors propose that their hybrid fabrication technique successfully produces complex, patient-derived vascular models. These phantoms demonstrate realistic visual characteristics across computed tomography, intravascular ultrasound, and transcutaneous ultrasound platforms. The study suggests these tools serve as effective aids for benchtop development of emerging imaging technologies. Researchers also highlight the potential for refining novel minimally invasive surgical procedures using these models. The findings indicate that the inclusion of a non-soluble spine provides a necessary radiological landmark for accurate navigation. The team concludes that their method offers a viable, low-cost alternative for creating high-fidelity anatomical structures. These models may improve the training experience for clinicians performing endovascular aneurysm repair. The work confirms that patient-specific data can be translated into functional, multimodality-compatible simulation tools.

The researchers propose a hybrid fabrication technique using 3D printing of water-soluble materials to create wall-less structures. These are embedded in tissue-mimicking substances, while a non-soluble spine provides a radiological landmark for navigation during imaging.

The phantom incorporates a non-soluble 3D printed spine, which acts as a radiological landmark. This component is necessary to provide spatial orientation during both radiation-based and ultrasound-based imaging procedures.

The phantom was validated using three distinct modalities: computed tomography, intravascular ultrasound, and transcutaneous ultrasound. Each modality produced realistic appearances, confirming the versatility of the materials used in the fabrication process.

The authors demonstrate the utility of the model during a simulated endovascular aneurysm repair procedure. This simulation involved the use of image fusion, highlighting the practical application of the phantom in surgical training environments.

The researchers propose that these models are suitable for the benchtop development of new imaging technologies. Furthermore, they suggest that the phantoms facilitate the refinement of minimally invasive surgical techniques, offering a safe environment for clinical skill acquisition.

The fabrication method utilizes low-cost materials to create high-fidelity, temperature-stable models. This approach contrasts with more expensive, single-modality phantoms that often lack the anatomical complexity of patient-derived vascular structures.