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Teerakanchana's equation transcends over 12 other LDL-C quantification formulae in the North Indian population

Ghulam Mehdi Dar1, Manoswini Dash1, Bhawna Mahajan2

  • 1Central Molecular Laboratory, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Jawaharlal Nehru Marg, New Delhi 110002, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 10, 2022
PubMed

Insights

Teerakanchana and Vujovic formulas show high accuracy for estimating Low-Density Lipoprotein-cholesterol (LDL-C) levels. These formulas may offer a reliable alternative to the Friedewald formula in North Indian healthcare settings.

Area of Science:

  • Clinical Chemistry
  • Cardiovascular Disease Biomarkers
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) mortality is rising globally.
  • Accurate Low-Density Lipoprotein-cholesterol (LDL-C) measurement is crucial for CVD risk assessment.
  • Friedewald's formula is widely used in India but its accuracy is debated.

Purpose of the Study:

  • To evaluate the accuracy of various formulas for LDL-C quantification.
  • To identify a formula that best agrees with direct LDL-C measurement methods.

Main Methods:

  • Lipid profiles were analyzed using a direct homogenous method (LDL-C_M).
  • LDL-C was calculated using 13 different formulas.
  • Statistical correlation and agreement analyses were performed against LDL-C_M.

Main Results:

  • Teerakanchana's formula demonstrated strong positive correlation (r=0.914) and agreement (Lin's CCC=0.929) with LDL-C_M.
  • Vujovic's formula also showed good correlation (r=0.903) and agreement (Lin's CCC=0.925).

Conclusions:

  • Teerakanchana and Vujovic formulas are highly accurate for LDL-C estimation.
  • These formulas may serve as effective replacements for Friedewald's formula in North Indian public healthcare.
Abstract

Keywords:
AtherosclerosisCardiovascular diseaseDyslipidemiaFriedewaldLDL-CTeerakanchana

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