Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

14.1K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
14.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

5.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hallermann-Streiff syndrome: A systematic review of the published literature.

Journal of oral biology and craniofacial research·2026
Same author

Diagnostic accuracy of fine-needle aspiration cytology in salivary gland neoplasms: a systematic review and meta-analysis.

Expert review of molecular diagnostics·2026
Same author

"Clinicopathological spectrum and survival outcomes in jaw osteosarcomas: a retrospective case series from an Indian tertiary centre".

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Solitary Mucosal Neuroma of the Hard Palate Without Multiple Endocrine Neoplasia Type 2B: A Rare Non-syndromic Case Report and Literature Review.

Cureus·2026
Same author

"Non-habit associated oral squamous cell carcinoma: A systematic review".

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Cytoplasmic Granules in Granular Cell Tumor and Congenital Epulis: A Histochemical and Immunohistochemical Note.

Head and neck pathology·2026

Related Experiment Video

Updated: Sep 27, 2025

Colony Forming Cell CFC Assay for Human Hematopoietic Cells
11:30

Colony Forming Cell CFC Assay for Human Hematopoietic Cells

Published on: December 18, 2010

35.9K

Ghost cells unveiled: A comprehensive review.

Aarushi Garg1, Rewa Malhotra1, Aadithya B Urs2

  • 1Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi 110002, India.

Journal of Oral Biosciences
|April 10, 2022
PubMed
Summary

Ghost cells (GCs) are characterized by unique keratinization, appearing in various lesions. Aberrant keratinization is the most accepted theory for their origin, though their exact role remains debated.

Keywords:
GhostKeratinizationOdontogenic cystOdontogenic tumorReview

More Related Videos

Analysis of Cell Suspensions Isolated from Solid Tissues by Spectral Flow Cytometry
11:08

Analysis of Cell Suspensions Isolated from Solid Tissues by Spectral Flow Cytometry

Published on: May 5, 2017

13.1K
Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells
10:20

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Published on: March 24, 2023

1.7K

Related Experiment Videos

Last Updated: Sep 27, 2025

Colony Forming Cell CFC Assay for Human Hematopoietic Cells
11:30

Colony Forming Cell CFC Assay for Human Hematopoietic Cells

Published on: December 18, 2010

35.9K
Analysis of Cell Suspensions Isolated from Solid Tissues by Spectral Flow Cytometry
11:08

Analysis of Cell Suspensions Isolated from Solid Tissues by Spectral Flow Cytometry

Published on: May 5, 2017

13.1K
Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells
10:20

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Published on: March 24, 2023

1.7K

Area of Science:

  • Oral pathology
  • Histopathology
  • Oncology

Background:

  • Ghost cells (GCs) are cells with intracytoplasmic keratinization, preserving cellular outlines and showing nuclear remnants.
  • GCs present in various patterns like degeneration, granulation, and calcification, with unclear histogenesis.
  • These cells are typical features of specific cystic lesions, odontogenic tumors, and non-odontogenic tumors.

Purpose of the Study:

  • To review hypotheses on ghost cell histogenesis and molecular pathogenesis.
  • To discuss diagnostic methods, including special staining and immunohistochemistry for GC identification.
  • To propose an algorithm for identifying lesions containing GCs and elucidate their prognostic role.

Main Methods:

  • Review of existing literature on ghost cell histogenesis.
  • Analysis of immunohistochemical studies and special staining characteristics.
  • Development of a diagnostic algorithm for lesions with GCs.

Main Results:

  • Aberrant keratinization is proposed as the most accepted hypothesis for GC origin.
  • Diagnostic workup and prognostic implications of GCs in various lesions are clarified.
  • A stepwise algorithm aids in identifying odontogenic and non-odontogenic lesions containing GCs.

Conclusions:

  • Ghost cells are a distinct feature in numerous odontogenic and non-odontogenic lesions.
  • Aberrant keratinization is the leading theory for GC histogenesis, supported by immunohistochemical evidence.
  • The pathognomonic role of GCs in the biological nature of these lesions remains a subject of controversy.