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Effects of Solcoderm.

I S Engelberg, M Ronnen, S Suster

    International Journal of Dermatology
    |November 1, 1986
    PubMed
    Summary
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    Solcoderm, a 5-fluorouracil and salicylic acid preparation, showed limited efficacy for basal cell carcinoma, with residual tumors in most patients. Treatment should be restricted to superficial types, avoiding morphea forms.

    Area of Science:

    • Dermatology
    • Oncology
    • Pharmacology

    Background:

    • Basal cell carcinoma (BCC) is the most common type of skin cancer.
    • Topical treatments are explored for non-invasive BCC management.
    • 5-fluorouracil and salicylic acid preparations are used in dermatological treatments.

    Purpose of the Study:

    • To evaluate the efficacy of a 5-fluorouracil and salicylic acid preparation (Solcoderm) in treating basal cell carcinoma.
    • To assess the depth of penetration and fibrotic changes induced by Solcoderm.
    • To determine the optimal clinical indications for Solcoderm in BCC treatment.

    Main Methods:

    • A study involving 24 patients diagnosed with basal cell carcinoma.
    • Treatment administered using a preparation containing 5-fluorouracil and salicylic acid (Solcoderm).

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  • Histopathological analysis to assess residual tumor and depth of fibrotic changes.

    • Main Results:

    • Two-thirds of patients exhibited residual tumor islands in the dermis post-treatment.
    • Complete tumor disappearance was observed in only one-third of the patients.
    • Fibrotic changes varied in depth: 0.34–0.40 cm for morphea BCC and 0.52–0.88 cm for conventional BCC.

    Conclusions:

    • Solcoderm demonstrated limited effectiveness in eradicating basal cell carcinoma.
    • The preparation is recommended only for superficial basal cell carcinomas.
    • Treatment with Solcoderm should be avoided for basal cell carcinomas of the morphea type.