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Behavioral characteristics of dopamine D5 receptor knockout mice
Hitomi Sasamori1, Toshiaki Asakura2, Chiaki Sugiura1
1Department of Neuropharmacology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Scientific Reports
|April 11, 2022
Summary
Dopamine D5 receptors are not essential for impulse control in mice. This study found no significant impact of D5 receptor deficiency on impulsivity or anti-impulsive drug response.
Area of Science:
- Neuroscience
- Psychopharmacology
- Behavioral Genetics
Background:
- Elevated impulsivity is a hallmark of psychiatric disorders like ADHD and schizophrenia.
- Current anti-impulsive treatments are limited, necessitating novel therapeutic targets.
Purpose of the Study:
- To investigate the role of dopamine D5 receptors in regulating impulse control.
- To assess the impact of D5 receptor knockout on spontaneous activity and learning/memory.
Main Methods:
- Utilized mice genetically engineered to lack dopamine D5 receptors (D5KO mice).
- Assessed spontaneous home cage activity and learning/memory using q-learning models.
- Compared behavioral adjustments and drug responses in D5KO and wild-type littermates.
Main Results:
- D5KO mice showed minor activity changes only at specific times.
- D5KO mice exhibited reduced behavioral adjustment post-impulsive actions.
- Baseline impulsivity and drug effects were comparable between D5KO and wild-type mice.
- Unlike other models, D5KO mice showed no deficits in locomotor activity, working memory, or learning.
Conclusions:
- Dopamine D5 receptors are dispensable for impulse control.
- Further research using time series and detailed learning analysis is needed to fully understand D5 receptor functions.
