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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Brainstem Diffusion Tensor Tractography and Clinical Applications in Pain.

Yu Zhang1, Ansgar J Furst1,2,3,4

  • 1War Related Illness and Injury Study Center (WRIISC), VA Palo Alto Health Care System, Palo Alto, CA, United States.

Frontiers in Pain Research (Lausanne, Switzerland)
|April 11, 2022
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Brainstem diffusion MRI tractography reveals human pathways connecting to subcortical and cortical regions. This advanced technique offers insights into neurotransmitter systems and shows promise for pain management research.

Keywords:
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Area of Science:

  • Neuroimaging
  • Neuroanatomy
  • Neurology

Background:

  • The brainstem is a critical structure vulnerable in neurological disorders like pain and neurodegeneration.
  • Diffusion tensor imaging (DTI) and tractography offer insights into brainstem fiber pathways.
  • Brainstem tractography faces challenges due to its location, size, and imaging limitations.

Purpose of the Study:

  • To review advances in diffusion tensor tractography for brainstem pathways.
  • To compare existing tractographic methods with a novel automated approach.
  • To explore neuroanatomical implications for neurotransmitter systems and pain.

Main Methods:

  • Overview of recent diffusion tensor tractography studies on brainstem connectivity.
  • Comparison of literature-based and in-lab automated brainstem tractography techniques.
  • Analysis of atlas building, technical advantages, and neuroanatomical relevance.

Main Results:

  • DTI tractography reveals human pathways linking the brainstem to subcortical and cortical regions.
  • Pathways exhibit distinct fiber distributions from brainstem neurotransmitter nuclei.
  • Automated tractography offers technical advantages and neuroanatomical insights.

Conclusions:

  • Brainstem tractography is advancing our understanding of brain connectivity.
  • The technique provides neuroanatomical insights into neurotransmitter systems.
  • Brainstem tractography shows potential as a tool for pain research.