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Impact of Regional Lymph Node Irradiation on Reducing Lymph Node Recurrence in Esophageal Cancer Patients
Shigenobu Watanabe1, Ichiro Ogino1, Daisuke Shigenaga1
1Department of Radiation Oncology, Yokohama City University Medical Center, Yokohama, Japan.
Background/Aim:
To evaluate the preventive effects of regional lymph node irradiation on lymph node recurrence in esophageal cancer (EC).
Patients And Methods:
The study included 289 patients who received definitive radiotherapy for EC. The regional lymph node area of group 1 was determined as the area with the highest probability of lymph node metastasis and group 2 was determined as the area with the next highest probability of lymph node metastasis depending on the primary site of EC.
Results:
The patients in whom group 2 was completely included in the irradiated field had a significantly lower rate of recurrence of regional lymph node metastasis than those in whom group 2 was not or insufficiently included (p=0.0337). There was no significant difference in overall survival (p=0.4627) or disease-specific survival (p=0.6174) between the two groups.
Conclusion:
Regional lymph node irradiation did not have survival-prolonging effects but significantly reduced regional lymph node recurrence.
