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Published on: January 10, 2025
Protective Effect and Mechanism of Traditional Chinese Medicine on Myocardial Ischemia Reperfusion Injury
Kuo Liu1, Demin Liu1, Wei Cui1
1Cardiology Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Insights
Traditional Chinese Medicine (TCM) offers protective effects against heart damage caused by restoring blood flow after a heart attack. This review explores TCM
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Integrative Medicine
Background:
- Acute myocardial infarction (AMI) necessitates rapid reperfusion to limit infarct size and improve outcomes.
- Ischemia-reperfusion (I/R) injury can paradoxically worsen outcomes by damaging reperfused heart tissue.
- Traditional Chinese Medicine (TCM) has a history of treating cardiovascular diseases with demonstrated efficacy.
Purpose of the Study:
- To review the protective mechanisms of TCM against myocardial I/R injury.
- To summarize current research advances in TCM for mitigating I/R injury.
Main Methods:
- Literature review of studies on TCM and myocardial I/R injury.
- Analysis of various TCMs and their active components.
- Examination of underlying protective mechanisms.
Main Results:
- Multiple TCMs and their components exhibit cardioprotective effects against I/R injury.
- Diverse mechanisms underlie TCM's protective actions, including antioxidant and anti-inflammatory pathways.
- Research highlights the potential of TCM in managing myocardial I/R injury.
Conclusions:
- TCM represents a promising therapeutic strategy for reducing myocardial I/R injury.
- Further research into TCM mechanisms can inform novel treatment approaches for post-infarction care.
Abstract:
After acute myocardial infarction, early restoration of myocardial perfusion by thrombolysis or percutaneous coronary intervention is the most effective way to reduce the size of myocardial infarction and improve clinical outcomes. However, recovery of blood flow to the ischemic myocardium may cause ischemia-reperfusion (I/R) injury, a phenomenon that instead reduces the efficacy of myocardial reperfusion. Traditional Chinese medicine (TCM) has long been used for the treatment of cardiovascular diseases and has shown remarkable efficacy. Many studies have shown that some TCMs and their active components can exert protective effects against myocardial I/R injury through different mechanisms. This review summarized the protective mechanisms and current research advances of TCMs in myocardial I/R injury.
