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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Current modalities of sickle cell disease management
Adekunle Sanyaolu1, Ejoke Agiri2, Carl Bertram2
1Federal Ministry of Health, Abuja, Nigeria.
Blood Science (Baltimore, Md.)
|April 11, 2022
Summary
Sickle cell disease (SCD) impacts many in the US, particularly African Americans. This paper reviews current management strategies for this inherited blood disorder, as no cure exists.
Area of Science:
- Hematology
- Genetics
- Public Health
Background:
- Sickle cell disease (SCD) affects nearly 100,000 individuals in the United States.
- The sickle gene is prevalent in 8% of Black Americans and up to 30% in some African populations.
- SCD is more common in individuals of African or African-American descent, causing various complications.
Purpose of the Study:
- To provide insight into current management and maintenance approaches for sickle cell disease.
- To highlight the importance of early diagnosis and treatment in reducing mortality rates.
- To discuss strategies for individuals living with SCD, given the absence of a cure.
Main Methods:
- Literature review of existing management strategies for SCD.
- Analysis of current approaches for disease management and maintenance.
- Synthesis of information on diagnostic and treatment protocols.
Main Results:
- SCD management is vital for survival due to the lack of a cure.
- Early diagnosis and treatment are crucial for reducing mortality.
- Various management and maintenance methods are currently employed.
Conclusions:
- Effective management is key to improving survival rates for individuals with SCD.
- Continued research and implementation of management strategies are essential.
- Understanding disease prevalence and genetic factors informs public health approaches.
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