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Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
Yuki Oshima1, Shintaro Fujii1, Kazuhiro Horiuchi1
1Department of Neurology, Hakodate Municipal Hospital, Japan.
Abstract:
Myasthenia gravis (MG) is an immune-related adverse event (irAE), and as an irAE, MG (irAE-MG) generally has a monophasic course, with only a few case reports of irAE-MG flare-ups during the course of the disease. We herein report a case of pembrolizumab-induced MG with relapsing symptoms. irAE-MG is a rare disease that has not yet been fully characterized, and our case shows that MG symptoms may relapse. Therefore, regular follow-up is necessary, even after the symptoms improve with immunosuppressive therapy.
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