Related Experiment Video
Updated: Sep 27, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
Published on: April 21, 2022
RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer's Disease
Runjiao Zhang1,2, Yizhou Zhang1,2,3, Fangzhen Guo1,2
1Department of Anatomy, Hebei Medical University, Shijiazhuang, China.
Abstract:
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention. m6A, the most common and abundant type of eukaryotic methylation modification in RNAs, is a dynamic reversible modification that regulates nuclear splicing, stability, translation, and subcellular localization of RNAs. These processes are involved in the occurrence and development of many diseases. An increasing number of studies have focused on the role of m6A modification in Alzheimer's disease, which is the most common neurodegenerative disease. This review focuses on the general features, mechanisms, and functions of m6A methylation modification and its role in Alzheimer's disease.
Related Concept Videos
RNA Editing
RNA Stability
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Nuclear Export of mRNA
Alzheimer's Disease: Treatment
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability

