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Lobar Cerebral Microbleeds Are Associated With Cognitive Decline in Patients With Type 2 Diabetes Mellitus

Pengfei Shao1,2,3, Hengheng Xu1,2,3, Xiaoning Sheng1,2,3

  • 1Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Frontiers in Neurology
|April 11, 2022
PubMed
Abstract

Insights

The total volume of cerebral microbleeds (CMBs) is a risk factor for cognitive impairment in type 2 diabetes mellitus (T2DM) patients. Lobar CMB volume specifically impacts working memory, suggesting CMBs as potential early warning signs.

Area of Science:

  • Neurology
  • Radiology
  • Endocrinology

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cognitive decline.
  • Cerebral microbleeds (CMBs) are small lesions in the brain that can be detected using neuroimaging.
  • The relationship between CMBs and cognitive function in T2DM patients requires further investigation.

Purpose of the Study:

  • To explore the distinct features of cerebral microbleeds (CMBs), including number, volume, and location.
  • To investigate the correlation between CMBs and cognitive ability in patients with type 2 diabetes mellitus (T2DM).

Main Methods:

  • Recruited 95 T2DM patients and 80 healthy controls (HC).
  • Utilized AccuBrain®, an automated tool, for CMB quantification (number and volume).
  • Assessed global cognition and five cognitive domains using a cognitive test battery.
  • Employed logistic and multivariate linear regression to analyze CMBs-cognition relationships.

Main Results:

  • Total CMB volume, but not number, was an independent risk factor for cognitive impairment in T2DM patients (OR = 0.332, p = 0.018).
  • Lobar CMB volume was significantly associated with impaired working memory (β = -0.239, p = 0.027).
  • No significant correlation was found between the number of CMBs (lobar or deep/infratentorial) and any cognitive domains.

Conclusions:

  • Lobar CMBs are linked to cognitive impairment in T2DM patients and may serve as an early warning sign.
  • Quantitative analysis of CMBs provides a more sensitive and objective measurement compared to simple counting.
  • These findings highlight the importance of CMB volume and location in understanding cognitive deficits in T2DM.
Keywords:
MRIcerebral microbleeds (CMBs)cognitive impairmentquantitative methodtype 2 diabetes mellitus

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