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Circulating Biomarkers in Lower Extremity Artery Disease
Louise Ziegler1, Ulf Hedin2, Anders Gottsäter3,4
1Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institute, Danderyd Hospital Stockholm, Sweden.
European Cardiology
|April 11, 2022
Summary
Lower extremity artery disease (LEAD) affects circulation due to narrowed arteries, often linked to atherosclerosis. Circulating biomarkers show promise for earlier diagnosis of this condition, especially in asymptomatic patients.
Area of Science:
- Vascular Medicine
- Biomarker Discovery
- Atherosclerosis Research
Background:
- Lower extremity artery disease (LEAD) is a chronic condition characterized by impaired circulation in the legs, primarily caused by atherosclerosis.
- It is prevalent in older populations and associated with significant cardiovascular risk factors and events.
- Many patients remain asymptomatic, hindering timely diagnosis and intervention.
Purpose of the Study:
- To provide a comprehensive review of circulating biomarkers investigated for lower extremity artery disease (LEAD).
- To discuss the clinical utility and potential of these biomarkers in facilitating earlier diagnosis.
- To explore the role of biomarkers in managing patients with LEAD.
Main Methods:
- Systematic literature review of studies investigating circulating biomarkers in LEAD.
- Analysis of biomarker performance in relation to LEAD diagnosis and severity.
- Evaluation of current clinical applications and future potential of biomarkers.
Main Results:
- Numerous circulating biomarkers have been explored for their association with LEAD.
- Biomarkers may aid in identifying individuals with LEAD, particularly those who are asymptomatic.
- The diagnostic and prognostic value of specific biomarkers requires further validation for clinical practice.
Conclusions:
- Circulating biomarkers represent a promising avenue for improving the early detection of lower extremity artery disease (LEAD).
- Further research and clinical validation are necessary to integrate these biomarkers into routine patient care.
- Biomarker-guided approaches could potentially enhance the management of LEAD and reduce associated cardiovascular risks.
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