Application of nanomaterials in proteomics-driven precision medicine

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Proteomics

Background:

• Nanostructured devices and nanoparticles have significantly impacted precision healthcare.
• Mass spectrometry (MS)-based proteomics has become crucial for identifying disease patterns, understanding pathology, and drug development.

Purpose of the Study:

• To review recent advances in nanoparticle design for enhanced enrichment of disease marker proteins and their post-translational modifications (PTMs).
• To summarize emerging nanotechnologies applied to MS-based proteomics for precision medicine discovery.

Main Methods:

• Review of literature on nanoparticle-assisted sample processing strategies for proteomics.
• Analysis of nanotechnology applications in MS-based proteome profiling and PTM characterization.
• Focus on enrichment techniques for marker proteins and PTMs from diverse bio-specimens.

Main Results:

• Synergy between nanotechnology and MS has expanded knowledge in human health and disease.
• Nanotechnology facilitates in-depth proteome profiling and PTM characterization.
• Advancements in nanoparticle design improve the enrichment of target analytes for MS.

Conclusions:

• Nanotechnology-assisted MS is a powerful tool for precision medicine discovery.
• Improved enrichment strategies enhance the identification of disease signatures and mechanisms.
• This synergy holds significant promise for developing novel diagnostics and therapeutics.