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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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Emulating interactions between microorganisms and tumor microenvironment to develop cancer theranostics.

Tongmeng Jiang1, Tao Yang1, Yingfan Chen1

  • 1School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

Theranostics
|April 11, 2022
PubMed
Summary

Microorganisms in the tumor microenvironment (TME) can influence cancer growth and are being explored as theranostic agents. Whole-metagenome sequencing aids in identifying these microbes for advanced cancer diagnosis and therapy.

Keywords:
cancer theranosticsmicrobiota spectramicroorganismstumor microenvironment (TME)

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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

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Area of Science:

  • Oncology
  • Microbiology
  • Immunology

Background:

  • Microorganisms inhabit the tumor microenvironment (TME) across various organs.
  • These microbes influence tumor progression through species-specific interactions within the TME.
  • Microorganism-TME interactions are being harnessed for novel cancer theranostic applications.

Purpose of the Study:

  • To review the characteristics of microorganisms in the TME.
  • To explore their interactions with the TME.
  • To discuss their current and potential applications in cancer diagnosis and therapy.

Main Methods:

  • Literature review of microorganism characteristics and TME interactions.
  • Analysis of current applications in cancer diagnosis and therapy.
  • Discussion of clinical trials and emerging technologies like whole-metagenome sequencing.

Main Results:

  • Microorganisms exhibit diverse roles in modulating the TME, impacting tumor growth.
  • Current research highlights the potential of microbes as cancer theranostic agents.
  • Whole-metagenome sequencing offers precise microbiota analysis for TME research.

Conclusions:

  • Understanding microorganism-TME interactions is crucial for developing advanced cancer theranostics.
  • Microbes can serve as probes, monitors, vaccines, or drugs in cancer care.
  • Emerging technologies facilitate the identification and application of TME microorganisms in clinical settings.