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Updated: Sep 27, 2025
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Aberrant dynamic functional connectivity features within default mode network in patients with autism spectrum
Huibin Jia1,2,3, Xiangci Wu1,2, Enguo Wang1,2
1Institute of Psychology and Behavior, Henan University, Kaifeng, 475004 China.
Autism spectrum disorder (ASD) is linked to altered brain network connectivity. This study reveals abnormal temporal dynamics in the default mode network (DMN) in ASD patients, correlating with symptom severity.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Psychiatry
Background:
- Autism spectrum disorder (ASD) is associated with atypical functional connectivity (FC) in brain networks.
- Previous studies noted lower default mode network FC (DMN-FC) in ASD but missed temporal dynamics and had small samples.
Purpose of the Study:
- To investigate the temporal dynamic patterns of DMN-FC in individuals with ASD.
- To determine if DMN-FC dynamics are associated with ASD symptom severity.
Main Methods:
- Utilized dynamical conditional correlation to analyze DMN-FC at each time point.
- Analyzed functional brain imaging data from over 1000 participants in the Autism Brain Imaging Data Exchange (ABIDE).
Main Results:
- ASD patients showed significantly lower mean DMN-FC and higher variance in DMN-FC compared to typical developing (TD) individuals.
- These DMN-FC alterations were significantly correlated with communication impairments and repetitive behaviors in ASD.
Conclusions:
- Aberrant temporal dynamics of DMN-FC are a key neuropathological feature in ASD.
- The identified DMN-FC dynamic patterns may serve as potential biomarkers for ASD diagnosis.
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