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Tomotherapy-based moderate hypofractionation for localized prostate cancer: a mono-institutional analysis
Maria Valentina Tenti1, Gianluca Ingrosso1, Vittorio Bini2
1Radiation Oncology Section, Department of Medicine and Surgery, University of Perugia, Italy.
Summary
Image-guided helical tomotherapy (HT) for localized prostate cancer (PCa) shows excellent survival rates and low toxicity. Smoking is a risk factor for metastasis after treatment.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Limited studies exist on image-guided helical tomotherapy (HT) for moderate hypofractionation in localized prostate cancer (PCa).
- This study reports outcomes and toxicity for localized PCa patients treated with HT-based moderate hypofractionated radiotherapy.
Purpose of the Study:
- To evaluate the efficacy and safety of helical tomotherapy (HT) in moderate hypofractionation for localized prostate cancer (PCa).
- To identify factors associated with treatment outcomes and toxicity.
Main Methods:
- Retrospective analysis of 76 localized PCa patients treated with HT.
- Prescribed doses of 60 Gy (20 × 3 Gy) or 67.5 Gy (25 × 2.7 Gy).
- Statistical analysis included Chi-squared test, Cox regression, and Kaplan-Meier survival analysis.
Main Results:
- At 4-year follow-up, overall survival (OS) was 91% and metastasis-free survival (MFS) was 89%.
- Smoking habit was significantly associated with MFS (HR 7.32, p=0.011).
- Low rates of acute and late grade ≥ 2 gastro-intestinal (GI) and genito-urinary (GU) toxicity were observed.
Conclusions:
- HT-based moderate hypofractionation is a safe and effective treatment for localized PCa with very low toxicity.
- Smoking cessation should be encouraged to reduce metastasis risk in PCa patients.
