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Updated: Sep 27, 2025
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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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Apixaban-Induced Hepatotoxicity
Umair Ansari1, Zahra Asghar1, Meghan Oswald2
1Internal Medicine, Mather Hospital, Northwell Health, Port Jefferson, USA.
Cureus
|April 11, 2022
Summary
Apixaban, a new anticoagulant, may cause severe liver injury (transaminitis) in some patients. Discontinuation of apixaban led to improvement in liver enzymes, suggesting a potential drug-induced liver injury.
Area of Science:
- Pharmacology
- Hepatology
- Clinical Medicine
Background:
- Apixaban is a widely prescribed direct oral anticoagulant for preventing and managing thromboembolic disorders.
- As a relatively new medication, the full spectrum of its adverse effects, including potential hepatotoxicity, is still under investigation.
Observation:
- A 61-year-old female patient with no previous history of liver dysfunction was initiated on apixaban therapy.
- Shortly after starting apixaban, the patient developed significant elevation in liver enzymes, indicative of severe transaminitis.
Findings:
- The patient's transaminase levels began to decrease following the discontinuation of apixaban.
- This clinical course suggests a probable association between apixaban initiation and the observed drug-induced liver injury.
Implications:
- This case highlights the importance of monitoring liver function in patients starting apixaban, especially those without pre-existing liver conditions.
- Further research is warranted to elucidate the mechanisms and incidence of apixaban-induced hepatotoxicity.
Keywords:
adult gastroenterologyapixabancardiology researchgeneral internal medicinegeneral pharmacologyhepatotoxicitylft - liver function testsMore Related Videos
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