Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

5' leader defects drive persistent HIV-1 viremia on long-term ART.

Nature communications·2026

Same author

Lethal Case of Bourbon Virus Leading to Shock and ECMO Utilization.

Case reports in infectious diseases·2026

Same author

Severe Anaplasmosis with Multi-Organ Failure in a Patient with Splenectomy: A Case Report.

Infectious disease reports·2025

Same author

A case of <i>W. chitiniclastica</i> bacteremia in a 38-year-old homeless male originating from a maggot-infested amputated foot.

IDCases·2025

Same author

Questions About the 2023 Infective Endocarditis Updated Criteria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024

Same author

Breakthrough invasive fungal infections on isavuconazole prophylaxis in hematologic malignancy & hematopoietic stem cell transplant patients.

Transplant infectious disease : an official journal of the Transplantation Society·2023

Search research articles

Related Experiment Video

Updated: Sep 27, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Ehrlichiosis mimicking acute leukemia.

Ra'ed Jabr¹, Wissam El Atrouni²

¹University of Miami Hospital and Clinics, Miami, FL, USA.

|April 11, 2022

Summary

Human monocytic ehrlichiosis, a tickborne illness, can mimic leukemia. Early diagnosis is crucial, as this Ehrlichia chaffeensis infection was initially mistaken for acute promyelocytic leukemia, leading to incorrect treatment.

Keywords:

Human monocytic ehrlichiosis Pancytopenia Tickborne illness

More Related Videos

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

Related Experiment Videos

Last Updated: Sep 27, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

Area of Science:

Infectious Diseases
Hematology
Tickborne Illnesses

Background:

Human monocytic ehrlichiosis presents with diverse clinical outcomes, from asymptomatic to fatal.
Ehrlichiosis can cause temporary white blood cell abnormalities that resemble leukemia or lymphoma.
Misdiagnosis as hematological malignancies has occurred in rare instances.

Observation:

A case of Ehrlichia chaffeensis infection presented with symptoms mimicking acute promyelocytic leukemia.
The patient received all-trans-retinoic acid therapy based on the initial misdiagnosis.

Findings:

Ehrlichia chaffeensis infection can present with pancytopenia and abnormal white blood cell counts.
The clinical and hematological findings of ehrlichiosis can be easily confused with hematological malignancies.

Implications:

Physicians should consider tickborne illnesses in the differential diagnosis for patients with pancytopenia.
Awareness of ehrlichiosis presentations is vital, especially in areas where tickborne diseases are endemic.
Prompt and accurate diagnosis of ehrlichiosis can prevent inappropriate and potentially harmful treatments.