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The Long Non-Coding RNA HOXC-AS3 Promotes Glioma Progression by Sponging miR-216 to Regulate F11R Expression

Yongshuai Li1, Lu Peng2, Xianwen Cao1

  • 1Department of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

Frontiers in Oncology
|April 11, 2022
PubMed

Insights

This study reveals that HOXC-AS3 promotes glioma progression by acting as a sponge for miR-216, ultimately upregulating F11R. This HOXC-AS3/miR-216/F11R axis offers potential new therapeutic targets for glioma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The role of long noncoding RNA HOXC-AS3 in glioma remains unclear.
  • HOXC-AS3 is implicated in the progression of various cancers.

Purpose of the Study:

  • To investigate the function and mechanism of HOXC-AS3 in glioma.
  • To explore the potential of the HOXC-AS3/miR-216/F11R axis as a therapeutic target for glioma.

Main Methods:

  • Analysis of HOXC-AS3 expression in glioma tissues and cells.
  • In vitro assays including qRT-PCR and luciferase reporter assays.
  • In vivo experiments using an intracranial glioblastoma mouse model.

Main Results:

  • HOXC-AS3 is overexpressed in glioma and associated with poor prognosis.
  • HOXC-AS3 acts as a competing endogenous RNA (ceRNA) by sponging miR-216, leading to F11R upregulation.
  • HOXC-AS3 promotes glioma malignant progression in vivo.

Conclusions:

  • The HOXC-AS3/miR-216/F11R axis is a key driver of glioma malignant progression.
  • This axis presents a potential therapeutic strategy for glioma treatment.
Keywords:
F11RHOXC-AS3ceRNAgliomamiR-216

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