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Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

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Related Experiment Video

Updated: Sep 27, 2025

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model

Published on: January 7, 2019

Life-Space Mobility and Parkinson's Disease. A Multiple-Methods Study.

Charlotte Ryder-Burbidge¹, Marguerite Wieler², Candace I J Nykiforuk¹

¹School of Public Health, University of Alberta Edmonton Alberta Canada.

Movement Disorders Clinical Practice

|April 11, 2022

Summary

This summary is machine-generated.

Life-space mobility (LSM) is impacted by individual, social, and environmental factors in Parkinson's disease (PD). Interventions should address these factors to improve mobility for people with PD.

Keywords:

Parkinson’s disease life‐space mobility qualitative research social participation survey

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Area of Science:

Neuroscience
Gerontology
Rehabilitation Science

Background:

Life-space mobility (LSM) is crucial for well-being but understudied in Parkinson's disease (PD).
Understanding factors affecting LSM in PD is essential for targeted interventions.

Purpose of the Study:

To explore individual, social, and environmental factors influencing LSM in people with PD.
To compare LSM between individuals with and without PD.

Main Methods:

A mixed-methods approach combining a cross-sectional survey (n=227) and qualitative narrative inquiry (n=10).
The University of Alabama Birmingham Life-Space Assessment (LSA) was used to measure LSM.
Multiple linear regression identified factors associated with LSM; interviews explored mobility facilitators and barriers.

Main Results:

Individuals with PD had slightly lower LSM scores than the comparison group, with a higher need for mobility assistance.
Factors associated with restricted LSM in PD included not driving, receiving caregiving, lower social participation, and reduced finances.
Qualitative data provided nuanced insights into built environment influences on mobility.

Conclusions:

Individual, social, and environmental factors significantly influence LSM in people with PD.
Interventions to enhance LSM in PD should adopt a holistic approach, considering both personal and community-level factors.