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Updated: Sep 27, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
The role of cholesterol metabolism in leukemia
Liang Zhao1, Huien Zhan2, Xinya Jiang1
1Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Abstract:
Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and drug resistance of leukemia. Exploring potential therapeutical targets related to cholesterol homeostasis is a promising area. This review summarized the functions of cholesterol and its derived intermediate metabolites, and also discussed potential agents targeting this metabolic vulnerability in leukemia.
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