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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.8K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Related Experiment Video

Updated: Sep 27, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Published on: January 10, 2019

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When blood development meets single-cell transcriptomics.

Jie Zhou1, Bing Liu1,2, Yu Lan2

  • 1State Key Laboratory of Proteomics, Translational Medicine Center of Stem Cells, Fifth Medical Center, General Hospital of PLA, Beijing, China.

Blood Science (Baltimore, Md.)
|April 11, 2022
PubMed
Summary
This summary is machine-generated.

This review explores how blood cells develop in embryos through distinct waves, focusing on hematopoietic stem cells (HSCs) generated via endothelial-to-hematopoietic transition. It highlights single-cell transcriptomics for understanding developmental hematopoiesis.

Keywords:
DevelopmentHematopoietic stem cellSingle-cell transcriptomics

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Area of Science:

  • Developmental Biology
  • Hematopoiesis
  • Genomics

Background:

  • Embryonic development involves three distinct waves of blood cell formation.
  • Hematopoietic stem cells (HSCs), crucial for lifelong blood production, originate during the third wave from hemogenic endothelium.
  • Endothelial-to-hematopoietic transition is the key process generating HSCs in mid-gestational embryos.

Purpose of the Study:

  • To review recent advancements in understanding distinct blood cell specification waves.
  • To focus on the generation of hematopoietic stem cells (HSCs) using single-cell technologies.
  • To discuss the application of single-cell transcriptional data in studying developmental hematopoiesis.

Main Methods:

  • Single-cell transcriptomic profiling techniques are discussed.
  • Functional evaluations are combined with single-cell transcriptional profiling.
  • Analysis of large-scale single-cell transcriptional datasets.

Main Results:

  • Recent studies using single-cell transcriptomics have revealed novel molecular insights into hematopoietic specification.
  • New findings illuminate the mechanisms underlying the generation of distinct blood cell waves, particularly HSCs.
  • Integration of single-cell data with functional studies provides a deeper understanding of developmental hematopoiesis.

Conclusions:

  • Single-cell transcriptomics is a powerful tool for dissecting developmental hematopoiesis.
  • Accumulating single-cell data offers significant potential for future research in blood cell development.
  • Further research integrating multi-omic single-cell data will advance our knowledge of HSC generation and function.