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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Ribosomal RNA Synthesis02:53

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
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Related Experiment Video

Updated: Sep 27, 2025

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
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Long non-coding RNAs during normal erythropoiesis.

Changlu Xu1,2, Lihong Shi1,2

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Hematological Disorders, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Blood Science (Baltimore, Md.)
|April 11, 2022
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial for normal red blood cell development. This review explores their diverse functions and regulatory mechanisms in erythropoiesis.

Keywords:
ErythropoiesisGlobin regulationHeme biosynthesisLong non-coding RNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Eukaryotic genomes extensively transcribe non-coding RNAs, including long non-coding RNAs (lncRNAs).
  • lncRNAs are prevalent in mammalian genomes and have emerged from recent transcriptomic studies.
  • While many lncRNA functions are uncharacterized, some are known to be vital in development and disease.

Purpose of the Study:

  • To review recent advancements in understanding the functions and mechanisms of lncRNAs in normal erythropoiesis.
  • To highlight the roles of lncRNAs in key erythroid processes.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of high-throughput transcriptomic data.
  • Synthesis of findings on lncRNA functions and mechanisms in erythropoiesis.

Main Results:

  • lncRNAs participate in various erythroid biological processes, including cell survival, heme metabolism, and globin regulation.
  • These roles are mediated through cis- or trans-acting molecular mechanisms.
  • Specific lncRNAs have been implicated in critical stages like erythroid enucleation.

Conclusions:

  • lncRNAs play significant, multifaceted roles in normal erythropoiesis.
  • Further investigation into lncRNA functions and mechanisms is warranted.
  • Understanding lncRNAs is key to comprehending red blood cell development and related disorders.